Knock in of a hexanucleotide repeat expansion in the C9orf72 gene induces ALS in rats.

Wei DongLi ZhangCaixian SunXiang GaoFeifei GuanJing LiWei ChenYuanwu Ma Lianfeng Zhang

Published in: Animal models and experimental medicine (2020)

Motor defects in KI rats may result from neurotoxicity caused by HRE and the resulting reduction in C9orf72 protein due to haploinsufficiency. These KI rats could be a useful model for investigating the contributions of loss-of-function to neurotoxicity in C9orf72-related ALS.

Keyphrases

neoadjuvant chemotherapy
amyotrophic lateral sclerosis
squamous cell carcinoma
genome wide
radiation therapy
gene expression
small molecule
dna methylation
protein protein
genome wide analysis