Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1.

Zeng-Yan HuangLing-Jun WangJia-Jia WangWen-Jun FengZhong-Qi YangShi-Hao NiYu-Sheng HuangHuan LiYi YangMing-Qing WangRong HuHeng WanChan-Juan WenShao-Xiang XianLu Lu

Published in: British journal of pharmacology (2018)

HB can serve as a novel natural food extract for preventing muscle wasting in chronic kidney disease and possibly other catabolic conditions.

Keyphrases

machine learning
transcription factor
binding protein
skeletal muscle
signaling pathway
oxidative stress
protein protein
amino acid
anti inflammatory
deep learning
small molecule