Sensory nerve-deficient microenvironment impairs tooth homeostasis by inducing apoptosis of dental pulp stem cells.

An-Qi LiuLi-Shu ZhangDong-Dong FeiHao GuoMei-Ling WuJin LiuXiao-Ning HeYong-Jie ZhangKun XuanBei Li

Published in: Cell proliferation (2020)

This research first demonstrates that sensory nerve-deficient microenvironment impairs tooth haemostasis by inducing apoptosis of DPSCs via activin B/SMAD2/3 signalling. Our study provides the evidence for the crucial role of sensory nerve in tooth homeostasis.

Keyphrases

stem cells
oxidative stress
endoplasmic reticulum stress
peripheral nerve
cell cycle arrest
cell death
transforming growth factor
signaling pathway
cell proliferation