Obese Male Mice Exposed to Early Life Stress Display Sympathetic Activation and Hypertension Independent of Circulating Angiotensin II.

Carolina DalmassoNermin S AhmedSundus GhuneimCole CincinelliJaqueline R LeachmanJorge F GianiLisa A Cassis Analia S Loria

Published in: Journal of the American Heart Association (2023)

Overall, elevated blood pressure and vasomotor sympathetic tone remained exacerbated in MSEW mice compared with controls after the peripheral inhibition of angiotensin-converting enzyme, suggesting a mechanism independent of angiotensin II.

Keyphrases

angiotensin ii
angiotensin converting enzyme
early life
blood pressure
vascular smooth muscle cells
hypertensive patients
adipose tissue
metabolic syndrome
heart rate
type diabetes
weight loss
high fat diet induced
blood glucose
chemotherapy induced