Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence.

Minhao ChenYingjuan LiLongfei XiaoGuangchun DaiPanpan LuYun-Feng Rui

Published in: Stem cell research & therapy (2021)

Our results demonstrate a critical role of noncanonical Wnt5a signaling in TSPCs senescence, and Wnt5a could be an attractive therapeutic target for antagonizing tendon aging.

Keyphrases

cell proliferation
stem cells
dna damage
endothelial cells
anterior cruciate ligament reconstruction
oxidative stress