TI17, a novel compound, exerts anti-MM activity by impairing Trip13 function of DSBs repair and enhancing DNA damage.

Shuaikang ChangWenqin XiaoYongsheng XieZhijian XuBo LiGuanli WangKe HuYong ZhangJinfeng ZhouDongliang SongHuabin ZhuXiaosong WuYumeng LuJumei ShiWeiliang Zhu

Published in: Cancer medicine (2023)

Our study suggests that TI17 could be acted as a specific inhibitor of Trip13 and supports a preclinical proof of concept for therapeutic targeting of Trip13 in MM.

Keyphrases

dna damage
oxidative stress
dna repair
stem cells
cell therapy
bone marrow