Preclinical activity of allogeneic SLAMF7-specific CAR T-cells (UCARTCS1) in multiple myeloma.

Charlotte L B M KorstChloe O'NeillWassilis S C BruinsMeliha CosovicInoka TwicklerChristie P M VerkleijDiane Le ClerreMaria ThemeliIsabelle Chion-SotinelSonja ZweegmanRoman GalettoTuna MutisNiels W C J van de Donk

Published in: Journal for immunotherapy of cancer (2024)

These results demonstrate that UCARTCS1 has potent anti-MM activity against MM cell lines and primary MM cells, as well as in an MM xenograft model and support the evaluation of UCARTCS1 in patients with advanced MM.

Keyphrases

multiple myeloma
induced apoptosis
bone marrow
stem cells
cell cycle arrest
cell proliferation
cell death
low dose