Prosthesis-Patient Mismatch in Small Aortic Annuli: Self-Expandable vs. Balloon-Expandable Transcatheter Aortic Valve Replacement.
Jerome FerraraAlexis TheronAlizee PortoPierre MoreraPaul LuporsiNicolas JaussaudVlad GariboldiFrederic CollartThomas CuissetPierre DeharoPublished in: Journal of clinical medicine (2022)
Prosthesis-patient mismatch (PPM) is associated with worse outcomes following surgical aortic valve replacement (SAVR). PPM has been identified in a significant proportion of TAVR, particularly in patients with small aortic annuli. Our objective was to evaluate the hemodynamic performances of balloon-expandable (BE) (Sapiens 3 TM ) versus two different self-expandable (SE) (Evolut Pro TM , Accurate Neo TM ) TAVR devices in patients with small aortic annulus defined by a computed tomography aortic annulus area (AAA) between 330 and 440 mm 2 . We enrolled 131 consecutive patients corresponding to 76 Sapiens 3 23 mm (58.0%), 26 Evolut Pro (19.9%) and 29 Accurate Neo (22.1%). Mean age was 82.5 ± 7.06 years, 22.9% of patients were male and mean Euroscore was 4.0%. Mean AAA was 374 ± 27 mm 2 for Sapiens 3, 383 ± 29 mm 2 for Corevalve Evolut Pro and 389 ± 25 mm 2 for Accurate Neo. BE devices were associated with significantly higher rates of PPM (39.5%) as compared to SE devices (15.4% for Corevalve Evolut Pro and 6.9% for Accurate Neo) ( p < 0.0001). Paravalvular leaks ≥ 2/4 were more often observed in SE devices (15.4% for Corevalve Evolut Pro and 17.2% for Accurate Neo) than in BE devices (2.6%) ( p = 0.007). In conclusion, SE TAVR devices did achieve better hemodynamic results despite higher rates of paravalvular leaks. Therefore, SE TAVI devices could be considered as first choice in small aortic anatomy.
Keyphrases
- aortic valve
- transcatheter aortic valve implantation
- transcatheter aortic valve replacement
- aortic valve replacement
- aortic stenosis
- ejection fraction
- end stage renal disease
- computed tomography
- chronic kidney disease
- high resolution
- newly diagnosed
- anti inflammatory
- left ventricular
- peritoneal dialysis
- coronary artery disease
- magnetic resonance imaging
- case report
- atrial fibrillation
- prognostic factors
- mass spectrometry
- coronary artery
- decision making