Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer.

Yu PanFengchun LuQinglin FeiXingxing YuPing XiongXunbin YuYuan DangZelin HouWenji LinXianchao LinZheyang ZhangMinggui PanHeguang Huang

Published in: Journal of hematology & oncology (2019)

Our data indicate that CD47 targeting induces compartmental remodeling of tumor-infiltrating immune cells of the TME in PDAC. Different PDAC mouse models exhibited differential response to the anti-CD47 and anti-PD-L1 blockade due to the differential effect of this combination treatment on the infiltrating immune cells and key immune activating genes in the TME established by the different PDAC cell lines.

Keyphrases

single cell
nk cells
mouse model
rna seq
cancer therapy
signaling pathway
high throughput
genome wide
gene expression
big data
dna methylation
replacement therapy
genome wide identification