Exercise Training Reduces Inflammation and Fibrosis and Preserves Myocardial Function and Perfusion in a Model of Chronic Chagas Cardiomyopathy.
Thayrine Rosa DamascenoDenise M TanakaEnrico F MagnaniRafael Dias de Brito OliveiraDanielle Aparecida Gomes PereiraIldernandes Vieira-AlvesVirginia S LemosJorge Mejia CabezaCamila G FabricioAlessandra A ResendeDawit Albieiro Pinheiro GonçalvesGustavo de Oliveira ZanettiEduardo E Vieira de CarvalhoMarcos Vinicius SimõesLuciano Fonseca Lemos de OliveiraPublished in: Arquivos brasileiros de cardiologia (2024)
Our study demonstrated that APT ameliorated cardiac dysfunction, MPD, and reduced inflammation and fibrosis in CCC hamster models. Additionally, CCC-SED animals presented skeletal muscle atrophy while CCC-APT animals showed preserved skeletal muscle CSA. Understanding APT's effects on CCC's pathophysiological dimensions is crucial for future research and therapeutic interventions.