Transcutaneous vagus nerve stimulation modulates depression-like phenotype induced by high-fat diet via P2X7R/NLRP3/IL-1β in the prefrontal cortex.

Shaoyuan LiYuzhengheng ZhangYu WangZixuan ZhangChen XinYifei WangPei-Jing Rong

Published in: CNS neuroscience & therapeutics (2024)

The P2X7R/NLRP3/IL-1β signaling pathway may play an important role in the antidepressant-like behavior of taVNS, which provides a promising mechanism for taVNS clinical treatment of diabetes combined with depression.

Keyphrases

high fat diet
prefrontal cortex
signaling pathway
insulin resistance
depressive symptoms
adipose tissue
type diabetes
sleep quality
cardiovascular disease
major depressive disorder
pi k akt
nlrp inflammasome
glycemic control
metabolic syndrome
combination therapy
replacement therapy