Computational and experimental modulation of a noisy chaotic neuronal system.

In this work, we study the interplay between chaos and noise in neuronal state transitions involving period doubling cascades. Our approach involves the implementation of a neuronal mathematical model under the action of neuromodulatory input, with and without noise, as well as equivalent experimental work on a biological neuron in the stomatogastric ganglion of the crab Cancer borealis. Our simulations show typical transitions between tonic and bursting regimes that are mediated by chaos and period doubling cascades. While this transition is less evident when intrinsic noise is present in the model, the noisy computational output displays features akin to our experimental results. The differences and similarities observed in the computational and experimental approaches are discussed.