CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility.
Mulong DuJunyi XinRui ZhengQianyu YuanZhihui WangHongliang LiuHanting LiuGuoshuai CaiDemetrios AlbanesStephen C LamAdonina TardónChu ChenStig Egil BojesenMaria Teresa LandiMattias J JohanssonAngela RischHeike BickeböllerHeinz-Erich WichmannGadi RennertSusanne M ArnoldPaul J BrennanJohn K FieldSanjay S SheteLoic Le MarchandGeoffrey LiuAngeline S AndrewLambertus A L M KiemeneyShanbeh Zienolddiny-NaruiKjell GrankvistMikael JohanssonNeil C CaporasoAngela CoxYun Chul HongWoon-Puay KohMatthew B SchabathMelinda C AldrichMeilin WangHongbing ShenFeng ChenZhengdong ZhangRayjean J HungChristopher Ian AmosWenjie JiaoPhilip LazarusDavid Chistopher ChristianiPublished in: Cancer research (2024)
The causal pathway connecting CYP2A6 genetic variability and activity, cigarette consumption, and lung cancer susceptibility in smokers highlights the need for behavior modification interventions based on host susceptibility for cancer prevention.