Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells.

Futoon Abedrabbu Al-RawashdeWan Rohani Wan TaibImilia Ismail Muhammad Farid JohanAbdullah Saleh Al-WajeehHamid Ali Nagi Al-Jamal

Published in: Asian Pacific journal of cancer prevention : APJCP (2021)

our results indicated that TQ inhibited cell growth of K562 cells via downregulation of BCR ABL/ JAK2/STAT3 and STAT5 signaling and reducing JAK2 and STAT5 protein levels.

Keyphrases

cell cycle arrest
induced apoptosis
tyrosine kinase
chronic myeloid leukemia
cell proliferation
signaling pathway
endoplasmic reticulum stress
acute lymphoblastic leukemia
oxidative stress
pi k akt
acute myeloid leukemia
bone marrow