Current trends in bone tissue engineering.
Marco MravicBruno PéaultAaron W JamesPublished in: BioMed research international (2014)
The development of tissue engineering and regeneration constitutes a new platform for translational medical research. Effective therapies for bone engineering typically employ the coordinated manipulation of cells, biologically active signaling molecules, and biomimetic, biodegradable scaffolds. Bone tissue engineering has become increasingly dependent on the merging of innovations from each of these fields, as they continue to evolve independently. This foreword will highlight some of the most recent advances in bone tissue engineering and regeneration, emphasizing the interconnected fields of stem cell biology, cell signaling biology, and biomaterial research. These include, for example, novel methods for mesenchymal stem cell purification, new methods of Wnt signaling pathway manipulation, and cutting edge computer assisted nanoscale design of bone scaffold materials. In the following special issue, we sought to incorporate these diverse areas of emphasis in order to reflect current trends in the field.
Keyphrases
- tissue engineering
- stem cells
- bone mineral density
- soft tissue
- bone loss
- signaling pathway
- bone regeneration
- mesenchymal stem cells
- induced apoptosis
- healthcare
- drug delivery
- postmenopausal women
- cell therapy
- single cell
- high throughput
- bone marrow
- body composition
- epithelial mesenchymal transition
- pi k akt
- endoplasmic reticulum stress
- single molecule