Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.
Li-Kai TsaiI-Hsin ChenChi-Chao ChaoHsueh-Wen HsuehHsin-Hsiung ChenYun-Hsin HuangRong-Wei WengTzu-Yun LaiYi-Chieh TsaiYeou-Ping TsaoShow-Li ChenPublished in: Journal of cachexia, sarcopenia and muscle (2021)
NRIP is a novel AChRα binding protein and involves structural NMJ formation, which acts as a scaffold to stabilize AChR-rapsyn-ACTN2 complexes. Anti-NRIP autoantibody is a novel autoantibody in MG and plays a detrimental role in MG with the coexistence of anti-AChR autoantibody.