Transient Leukoerythroblastic Reaction in a Newborn with Rh-Incompatibility and Hemolysis: Case Report and Literature Review.
Gashaw AregaHenock GashawNuru Muhammed FedluWondwossen ErgetePublished in: Pediatric health, medicine and therapeutics (2023)
Leukoerythroblastosis is rarely encountered in clinical practice and is characterized by the presence of leukocytosis and erythroid and myeloid blast cells in peripheral blood. The most common causes of leukoerythroblastosis in early childhood are viral infection, juvenile myelomonocytic leukemia, and osteopetrosis. To the best of our knowledge, leukoerythroblastic reactions associated with hemolysis have not been previously reported in newborns. Here, we report a 24-hour-old female term newborn diagnosed with a leukoerythroblastic reaction, severe anemia, and neonatal hyperbilirubinemia secondary to Rh incompatibility based on presentation, laboratory determination, and peripheral morphology. A high index of clinical suspicion is required to avoid life-threatening complications among health professionals in the neonatal care unit.
Keyphrases
- peripheral blood
- clinical practice
- healthcare
- induced apoptosis
- bone marrow
- acute myeloid leukemia
- gestational age
- cell cycle arrest
- red blood cell
- blood pressure
- palliative care
- preterm infants
- pregnant women
- chronic kidney disease
- early onset
- dendritic cells
- quality improvement
- low birth weight
- endoplasmic reticulum stress
- cerebral ischemia
- cord blood
- cell death
- iron deficiency
- mass spectrometry
- brain injury
- high resolution
- preterm birth
- health insurance