Interleukin-22 Ameliorates Neutrophil-Driven Nonalcoholic Steatohepatitis Through Multiple Targets.

Seonghwan HwangYong HeXiaogang XiangWonhyo SeoSeung-Jin KimJing MaTian-Yi RenSeol Hee ParkZhou ZhouDechun FengGeorge KunosBin Gao

Published in: Hepatology (Baltimore, Md.) (2020)

Hepatic overexpression of CXCL1 is sufficient to drive steatosis-to-NASH progression in HFD-fed mice through neutrophil-derived reactive oxygen species and activation of stress kinases, which can be reversed by IL-22 treatment via the induction of metallothionein.

Keyphrases

reactive oxygen species
high fat diet
high fat diet induced
insulin resistance
cell proliferation
mouse model
metabolic syndrome
adipose tissue
type diabetes
heat stress
wild type
smoking cessation