Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?

Jennifer Lee Spiegel Mark JakobMarie KruizengaSaskia FreytagMattis BertlichMartin CanisFriedrich Ihler Frank Haubner Julia Kitz Bernhard G Weiss

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2020)

In conclusion, our study did not find a significant correlation of the investigated CSCs with survival estimates in adenocarcinoma of the major salivary glands. Recapitulating the results of our study in conjunction with data in the literature, the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2 do not seem to serve as reliable prognostic parameters in the treatment of adenocarcinoma of the salivary glands.

Keyphrases

cancer stem cells
squamous cell carcinoma
systematic review
stem cells
transcription factor
machine learning
radiation therapy
physical activity
deep learning
artificial intelligence
electronic health record
weight loss
smoking cessation
embryonic stem cells