Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?
Jennifer Lee SpiegelMark JakobMarie KruizengaSaskia FreytagMattis BertlichMartin CanisFriedrich IhlerFrank HaubnerJulia KitzBernhard G WeissPublished in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2020)
In conclusion, our study did not find a significant correlation of the investigated CSCs with survival estimates in adenocarcinoma of the major salivary glands. Recapitulating the results of our study in conjunction with data in the literature, the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2 do not seem to serve as reliable prognostic parameters in the treatment of adenocarcinoma of the salivary glands.