Long-term reversal of diabetes by subcutaneous transplantation of pancreatic islet cells and adipose-derived stem cell sheet using surface-immobilized heparin and engineered collagen scaffold.
Yang Hee KimJae Hyung KoSong LeeJu Yun OhGi Seok JeongSi-Nae ParkIn Kyong ShimSong Cheol KimPublished in: BMJ open diabetes research & care (2021)
The findings indicate the potential of the HCA-islet sheet to enhance islet revascularization and engraftment in a hADSC dose-dependent manner, following clinical islet transplantation for the treatment of diabetes mellitus.
Keyphrases
- stem cells
- induced apoptosis
- type diabetes
- glycemic control
- cardiovascular disease
- cell therapy
- venous thromboembolism
- coronary artery bypass grafting
- oxidative stress
- risk assessment
- adipose tissue
- metabolic syndrome
- coronary artery disease
- atrial fibrillation
- mass spectrometry
- wound healing
- endoplasmic reticulum stress