Integracide derivatives produced by endophyte Fusarium armeniacum M-3 isolated from Digitaria ciliaris .

Shiho SatoFerry Ferdiansyah SofianDradre Atakuru PaulinSho KobayashiTakuya KosekiYoshihito Shiono

Published in: Natural product research (2023)

Two new integracides, dedimethyl integracide B ( 1 ) and integracide K ( 2 ), were isolated from rice cultures of Fusarium armeniacum M-3, an endophyte isolated from Digitaria ciliaris , together with the known terpenoids, integracide B ( 3 ) and 2-deoxy-integracide B ( 4 ). Assignment of the signals in the 1 H and 13 C NMR spectra of 1 and 2 was achieved using DEPT, HMQC, HMBC, and NOESY spectra. Compound 2 exhibited moderate cytotoxicity against HeLa cells.

Keyphrases

cell cycle arrest
induced apoptosis
density functional theory
cell death
magnetic resonance
high resolution
high intensity
pi k akt
endoplasmic reticulum stress
solid state
mass spectrometry
cell proliferation