Dexmedetomidine attenuates haemorrhage-induced thalamic pain by inhibiting the TLR4/NF-κB/ERK1/2 pathway in mice.
Tianfeng HuangYong LiWenqing HuDapeng YuJu GaoFan YangYingying XuZehua WangLiang ZongPublished in: Inflammopharmacology (2021)
Our findings suggest that DEX alleviates the inflammatory response during thalamic pain through the TLR4/NF-κB/ERK1/2 signalling pathway and might be a potential therapeutic agent for thalamic pain.
Keyphrases
- signaling pathway
- inflammatory response
- chronic pain
- lps induced
- pi k akt
- deep brain stimulation
- pain management
- neuropathic pain
- toll like receptor
- nuclear factor
- lipopolysaccharide induced
- immune response
- cell proliferation
- oxidative stress
- spinal cord injury
- acute kidney injury
- postoperative pain
- endothelial cells