12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs.

T MochimaruKoichi FukunagaJ MiyataM MatsusakaK MasakiH KabataS UedaY SuzukiT GotoD UrabeM InoueY IsobeM AritaT Betsuyaku

Published in: Allergy (2017)

These results demonstrated that EPA alleviated airway eosinophilic inflammation through its conversion into bioactive metabolites. Additionally, our results suggest that 12-OH-17,18-EpETE is a potential therapeutic target for the management of asthma.

Keyphrases

chronic rhinosinusitis
oxidative stress
chronic obstructive pulmonary disease
ms ms
lung function
allergic rhinitis
mouse model
human health