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Influenza-Associated Excess Mortality by Age, Sex, and Subtype/Lineage: Population-Based Time-Series Study With a Distributed-Lag Nonlinear Model.

Li LiZe-Lin YanLei LuoWenhui LiuZhou YangChen ShiBo-Wen MingJun YangPeihua CaoChun-Quan Ou
Published in: JMIR public health and surveillance (2023)
Influenza was associated with substantial mortality in Guangzhou, occurring predominantly in the elderly, even after considering mortality displacement. The mortality burden of influenza B, particularly B/Yamagata, cannot be ignored. Contrasting sex differences were found in influenza-associated excess mortality from respiratory diseases and from cardiovascular diseases; the underlying mechanisms need to be investigated in future studies. Our findings can help us better understand the magnitude and time-course of the effect of influenza on mortality and inform targeted interventions for mitigating the influenza mortality burden, such as immunizations with quadrivalent vaccines (especially for older people), behavioral campaigns, and treatment strategies.
Keyphrases
  • cardiovascular events
  • risk factors
  • cardiovascular disease
  • metabolic syndrome
  • type diabetes
  • physical activity
  • coronary artery disease
  • drug delivery
  • single molecule