Shrinkage versus fragmentation response in neoadjuvantly treated oesophageal adenocarcinoma: significant prognostic relevance.
Cristina Graham MartinezSonay Kus ÖztürkAli Al-KaabiMaria J ValkemaJohn-Melle BokhorstCamiel RosmanHeidi RüttenCarla A P WautersMichail DoukasJoseph Jan-Baptist van LanschotPeter D SiersemaIris D NagtegaalRachel Sofia van der PostPublished in: Histopathology (2022)
The validation cohort confirmed these findings, although had more advanced cases (case-stages = III/IV 91 versus 73%, P = 0.005) and a higher prevalence of fragmented-pattern cases (80 versus 60%, P = 0.002). When combining the cohorts in multivariate analysis, the pattern of response was an independent prognostic factor [hazard ratio (HR) = 1.76, 95% CI = 1.0-3.0]. In conclusion, we established an externally validated, reproducible and clinically relevant classification of tumour response.