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Genetic and behavioral adaptation of Candida parapsilosis to the microbiome of hospitalized infants revealed by in situ genomics, transcriptomics, and proteomics.

Patrick T WestSamantha L PetersMatthew R OlmFeiqiao B YuHaley GauseYue Clare LouBrian A FirekRobyn BakerAlexander D JohnsonMichael J MorowitzRobert L HettichJillian F Banfield
Published in: Microbiome (2021)
The results reveal potentially medically relevant differences in Candida function in gut vs. laboratory environments, and constrain evolutionary processes that could contribute to hospital strain persistence and transfer into premature infant microbiomes. Video abstract.
Keyphrases
  • single cell
  • genome wide
  • candida albicans
  • biofilm formation
  • dna methylation
  • mass spectrometry
  • healthcare
  • copy number
  • pseudomonas aeruginosa
  • escherichia coli
  • gene expression
  • cystic fibrosis