Chromoplexy Is a Frequent Early Clonal Event in EWSR1-Rearranged Round Cell Sarcomas That Can Be Detected Using Clinically Validated Targeted Sequencing Panels.

Josephine Kam Tai K Dermawan Emily K Slotkin William D Tap Paul A Meyers Leonard H Wexler John H Healey Fabio Vanoli Chad M Vanderbilt Cristina R Antonescu

Published in: Cancer research (2024)

Chromoplexy is detectable using targeted NGS in a substantial portion of EWSR1-rearranged round cell sarcomas as an early and persistent clonal event, expanding the genomic complexity of fusion-associated sarcomas.

Keyphrases

single cell
high grade
cell therapy
cancer therapy
stem cells
gene expression
copy number
mesenchymal stem cells