Functionalization of PLGA Nanoparticles with 1,3-β-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages.

Matshawandile TukululaLuis GouveiaPaulo PaixaoRose HayeshiBrendon NaickerAdmire Dube

Published in: Pharmaceutical research (2018)

Functionalization of PLGA NPs with 1,3-β-glucan resulted in faster uptake of rifampicin into macrophages. These NPs may be useful to achieve rapid intracellular eradication of Mycobacterium tuberculosis.

Keyphrases

mycobacterium tuberculosis
drug delivery
pulmonary tuberculosis
drug release
reactive oxygen species
bone regeneration
oxide nanoparticles
cell wall
helicobacter pylori infection
loop mediated isothermal amplification
sensitive detection
quantum dots