Intimal and medial arterial changes defined by ultra-high-frequency ultrasound: Response to changing risk factors in children with chronic kidney disease.
Frida DangardtMarietta CharakidaScott ChiesaDevina BhowruthAlicja RapalaDaniela ThurnFranz SchaeferJohn DeanfieldRukshana ShroffPublished in: PloS one (2018)
Using UHFUS, we have shown that CKD is associated with exclusively medial arterial changes that attenuate when the uremic milieu is ameliorated after transplantation. In contrast, after transplantation intimal disease develops as hypertension and obesity become prevalent, representing rapid vascular remodeling in response to a changing cardiovascular risk factor profile.
Keyphrases
- high frequency
- risk factors
- chronic kidney disease
- transcranial magnetic stimulation
- end stage renal disease
- blood pressure
- insulin resistance
- metabolic syndrome
- type diabetes
- young adults
- magnetic resonance
- cell therapy
- magnetic resonance imaging
- high resolution
- weight gain
- high fat diet induced
- skeletal muscle
- loop mediated isothermal amplification
- contrast enhanced ultrasound