Porphyromonas gingivalis outer membrane vesicles in cerebral ventricles activate microglia in mice.
Kayo YoshidaKaya YoshidaMariko SeyamaYuka HiroshimaMana MekataNatsumi FujiwaraYasusei KudoKazumi OzakiPublished in: Oral diseases (2022)
Pg OMVs, including gingipains, can reach the cerebral ventricle and induce neuroinflammation by activating microglia. Pg OMVs may provide a better understanding of the implications of periodontal diseases in neurodegenerative conditions such as AD.
Keyphrases
- subarachnoid hemorrhage
- inflammatory response
- cerebral ischemia
- neuropathic pain
- lipopolysaccharide induced
- lps induced
- brain injury
- pulmonary artery
- pulmonary hypertension
- high fat diet induced
- mitral valve
- cognitive impairment
- heart failure
- spinal cord
- metabolic syndrome
- adipose tissue
- pulmonary arterial hypertension
- congenital heart disease
- left ventricular
- wild type