Flow Cytometry Characterization of Pluripotent Transmembrane Glycoproteins on Resident Cervix Uteri Cells in Patients Screened for Cervical Cancer.
Nicola ColacurciMaria Teresa SchettinoVincenzo GrimaldiFrancesco Paolo De LucaGelsomina MansuetoDario CostaFrancesco CacciatorePasquale De FranciscisClaudio NapoliPublished in: Cancer investigation (2020)
The aim of this study was to characterize both by flow cytometry analysis and immunohistochemistry cervix uteri cells of nulliparous women screened for cervical intraepithelial neoplasia (CIN) in comparison to a group without CIN by using mesenchymal stem cell-like and hematopoietic lineage markers. A significant expression for CD29, CD38, HLA-I, and HLA-II was correlated positively to the CIN degree and it was more relevant in patients positive for human papilloma virus (HPV). Thus, identification and detailed characterization of pluripotent resident in uteri cells could be a promising therapeutic target.
Keyphrases
- flow cytometry
- induced apoptosis
- end stage renal disease
- ejection fraction
- cell cycle arrest
- newly diagnosed
- chronic kidney disease
- high grade
- mesenchymal stem cells
- peritoneal dialysis
- prognostic factors
- endoplasmic reticulum stress
- patient safety
- preterm birth
- quality improvement
- patient reported outcomes
- type diabetes
- signaling pathway
- cell death
- cell proliferation
- skeletal muscle
- insulin resistance
- pi k akt
- cell fate
- breast cancer risk