14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis.

Wenyu FuAubryanna HettinghouseYujianan ChenWenhuo HuXiang DingMeng ChenYuanjing DingJyoti MundraWenhao SongRonghan LiuYoung-Su YiMukundan AtturJonathan SamuelsEric StraussPhilipp LeuchtRan SchwarzkopfChuan-Ju Liu

Published in: Annals of the rheumatic diseases (2021)

This study identifies 14-3-3ε as an inducible component of TNFR2 receptor complex in response to PGRN in chondrocytes and presents a previously unrecognised TNFR2 pathway in the pathogenesis of OA.

Keyphrases

knee osteoarthritis
rheumatoid arthritis
genome wide
binding protein
gene expression
dna methylation
extracellular matrix