Bone morphogenetic protein-2 enhances gonadotropin-independent follicular development via sphingosine kinase 1.

Masami ItoOsamu YoshinoYosuke OnoAkemi Yamaki-UshijimaTomoko TanakaTomoko ShimaMakoto OrisakaAkira IwaseAkitoshi Nakashima Shigeru Saito

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)

This is a first report showing that BMP-2 up-regulated SPHK1 mRNA expression in GCs and promoted GCs proliferation through Hippo pathway suppression. Thus, BMP-2 contributes to Gn-independent folliculogenesis via SPHK1, suggesting a potential therapeutic strategy for the POR patients with follicular dysgenesis.

Keyphrases

mesenchymal stem cells
bone regeneration
signaling pathway
transcription factor
protein kinase
tyrosine kinase
bone marrow