Arbutin abrogates cisplatin-induced hepatotoxicity via upregulating Nrf2/HO-1 and suppressing genotoxicity, NF-κB/iNOS/TNF-α and caspase-3/Bax/Bcl2 signaling pathways in rats.
Irmak Ferah OkkayAdemola Clement FamurewaCemil BayramUfuk OkkayAli Sefa MendilSelma SezenTeslime AyazIbrahim GeciliMustafa ÖzkaracaSelcuk SenyaylaAhmet HacımüftüoğluPublished in: Toxicology research (2024)
The findings demonstrate that ARB is a potential protective adjuvant against cisplatin-induced hepatotoxicity via inhibition of hepatic oxidative stress, inflammation, and apoptosis.
Keyphrases
- oxidative stress
- induced apoptosis
- signaling pathway
- pi k akt
- drug induced
- cell cycle arrest
- diabetic rats
- ischemia reperfusion injury
- dna damage
- rheumatoid arthritis
- early stage
- endoplasmic reticulum stress
- epithelial mesenchymal transition
- cell death
- nitric oxide synthase
- human health
- nitric oxide
- cell proliferation
- lps induced
- oxide nanoparticles