FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice.
Liang KuangJiangyi WuNan SuHuabing QiHangang ChenSiru ZhouYan XiongXiaolan DuQiaoyan TanJing YangMin JinFengtao LuoJunjie OuyangBin ZhangZuqiang WangWanling JiangLiang ChenShuai ChenZiming WangPeng LiuLiangjun YinFengjin GuoChuxia DengDi ChenChuan-Ju LiuYangli XieZhenhong NiLin ChenPublished in: Annals of the rheumatic diseases (2019)
Our study identifies the role of FGFR3 in synovial macrophage recruitment and synovitis, which provides a new insight into the pathological mechanisms of inflammation-related arthritis.