Profiling of the genetic features of Chinese patients with gastric cancer with HRD germline mutations in a large-scale retrospective study.

Chenghai ZhangDandan ZhuYurong QuMin ShiJingjiao MaYebo PengBowen ZhuHouquan TaoTonghui MaTieying Hou

Published in: Journal of medical genetics (2023)

Our data suggest that carrying both HRD and MMR gene LoF germline mutations may cause early-onset GC. Germline mutations in the HRD gene should be of concern in the study of hereditary GC.

Keyphrases

early onset
genome wide
dna repair
copy number
late onset
genome wide identification
gene expression
single cell
dna damage
electronic health record
machine learning
high resolution
transcription factor