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The complete genome sequence of the lumpy skin disease virus vaccine Herbivac LS reveals a mutation in the superoxide dismutase gene homolog.

Nicola DouglassAnelda Van Der WaltRuzaiq OmarHenry MunyandukiAnna-Lise Williamson
Published in: Archives of virology (2019)
The lumpy skin disease virus (LSDV) vaccine, Herbivac LS, batch 008, was sequenced and found to differ from the Neethling vaccine strain in the locus encoding a superoxide dismutase (SOD) homolog. The presence of a SOD homolog, be it full-length (as in Herbivac LS) or truncated (as in Neethling) may affect vaccine immunogenicity.
Keyphrases
  • disease virus
  • hydrogen peroxide
  • wound healing
  • genome wide
  • gene expression
  • copy number
  • nitric oxide