Lignan Glycosides from Urena lobata.
Yuan LuoCong SuNing DingBowen QiFangfang JiaXiping XuXiao LiuJuan WangXiaohui WangPengfei TuShe-Po ShiPublished in: Molecules (Basel, Switzerland) (2019)
Four new lignan glycosides; urenalignosides A-D (1-4), along with 12 known ones (5-16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2-4; 6; 7; 10; and 11 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC50 values in the range of 25.5-98.4 μM (positive control; quercetin; IC50 = 7.2 ± 0.2 μM).
Keyphrases
- lipopolysaccharide induced
- nitric oxide
- inflammatory response
- induced apoptosis
- high resolution
- cell cycle arrest
- molecular docking
- magnetic resonance
- electronic health record
- adipose tissue
- nitric oxide synthase
- hydrogen peroxide
- liquid chromatography
- cell death
- solid state
- mass spectrometry
- machine learning
- gas chromatography