Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2) regulates a network of calcium-handling genes in the injured heart.

Monika M GladkaArwa KohelaAnne E de LeeuwBas MolenaarDanielle VersteegLieneke KooijmanMariska van GeldorpWillem B van HamRocco CaliandroJody J HaighToon A B van VeenEva van Rooij

Published in: Cardiovascular research (2024)

Together, we present ZEB2 as a central regulator of contractility and Ca2+-handling components in the mammalian heart. Further mechanistic understanding of the role of ZEB2 in regulating Ca2+ homeostasis in cardiomyocytes is an essential step towards the development of improved therapies for HF.

Keyphrases

epithelial mesenchymal transition
long non coding rna
heart failure
transcription factor
binding protein
atrial fibrillation
genome wide
signaling pathway
protein kinase
endothelial cells
cancer therapy
dna binding
acute heart failure
oxide nanoparticles