Deletion of NADPH oxidase 2 in chondrocytes exacerbates ethanol-mediated growth plate disruption in mice without major effects on bone architecture or gene expression.

K PedersenJames WattC MaimoneH HangA DenysK SchroderL J SuvaJ-R ChenMartin J J Ronis

Published in: Alcohol, clinical & experimental research (2023)

Although Nox enzymatic activity regulates growth plate development, ethanol-associated disruption of the growth plate morphology is independent of ethanol-mediated increases in Nox2 activity.

Keyphrases

gene expression
reactive oxygen species
bone mineral density
metabolic syndrome
extracellular matrix