Impact of anticoagulation therapy on the cognitive decline and dementia in patients with non-valvular atrial fibrillation (cognitive decline and dementia in patients with non-valvular atrial fibrillation [CAF] trial).
Thomas Jared BunchHeidi MayMichael CutlerScott C WollerVictoria JacobsScott M StevensJohn CarlquistKirk U KnowltonJoseph B MuhlesteinBenjamin A SteinbergJeffrey L AndersonPublished in: Journal of arrhythmia (2022)
Use of dabigatran and well-managed warfarin therapy were associated with similar risks of stroke, cognitive decline, and dementia at 2 years, suggestive that either strategy is acceptable. The results of this Vanguard study did not support the pursuit of a larger formally powered study.
Keyphrases
- cognitive decline
- atrial fibrillation
- mild cognitive impairment
- oral anticoagulants
- catheter ablation
- left atrial
- direct oral anticoagulants
- left atrial appendage
- heart failure
- percutaneous coronary intervention
- stem cells
- venous thromboembolism
- clinical trial
- acute coronary syndrome
- risk assessment
- coronary artery disease
- human health
- cell therapy
- blood brain barrier
- smoking cessation
- bone marrow
- subarachnoid hemorrhage