Copy number alterations are associated with metastatic-lethal progression in prostate cancer.

Xiaoyu WangCatherine S GrassoKristina M JordahlSuzanne KolbYaw A NyameJonathan L WrightElaine A OstranderDean A TroyerRaymond LanceZiding FengJames Y DaiJanet L Stanford

Published in: Prostate cancer and prostatic diseases (2020)

This study shows that CNAs can be reliably detected from HM450K-based DNA methylation data. There are 11 recurrent CNAs showing association with metastatic-lethal events following RP and improving prediction over Gleason score. Genes affected by these CNAs may functionally relate to tumor aggressiveness and metastatic progression.

Keyphrases

copy number
prostate cancer
genome wide
dna methylation
squamous cell carcinoma
small cell lung cancer
mitochondrial dna
radical prostatectomy
gene expression
big data
electronic health record
machine learning
transcription factor
bioinformatics analysis
genome wide analysis