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Post-Cardiac Arrest: Mechanisms, Management, and Future Perspectives.

Taline LazzarinCarolina Rodrigues TononDanilo MartinsEdson Luiz FáveroThiago Dias BaumgratzFilipe Welson Leal PereiraVictor Rocha PinheiroRaquel Simões BallarinDiego Aparecido Rios QueirozPaula Schmidt AzevedoBertha Furlan PolegatoMarina Politi OkoshiLeonardo ZornoffSergio Alberto Rupp de PaivaMarcos Ferreira Minicucci
Published in: Journal of clinical medicine (2022)
Cardiac arrest is an important public health issue, with a survival rate of approximately 15 to 22%. A great proportion of these deaths occur after resuscitation due to post-cardiac arrest syndrome, which is characterized by the ischemia-reperfusion injury that affects the role body. Understanding physiopathology is mandatory to discover new treatment strategies and obtain better results. Besides improvements in cardiopulmonary resuscitation maneuvers, the great increase in survival rates observed in recent decades is due to new approaches to post-cardiac arrest care. In this review, we will discuss physiopathology, etiologies, and post-resuscitation care, emphasizing targeted temperature management, early coronary angiography, and rehabilitation.
Keyphrases
  • cardiac arrest
  • cardiopulmonary resuscitation
  • public health
  • healthcare
  • ischemia reperfusion injury
  • palliative care
  • quality improvement
  • drug delivery
  • cancer therapy