Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function.

Verena DeutschmeyerJanina BreuerSara K WaleschAnna M SokolJohannes GraumannMarek BartkuhnThomas BoettgerOliver RossbachAntje M Richter

Published in: Clinical epigenetics (2019)

ZAR1 is a novel cancer biomarker for lung and kidney, which is epigenetically silenced in various cancers by DNA hypermethylation. ZAR1 exerts its tumour suppressive function in part through p53 and through its zinc-finger domain. Epigenetic therapy can reactivate the ZAR1 tumour suppressor in cancer.

Keyphrases

papillary thyroid
squamous cell
dna methylation
gene expression
lymph node metastasis
squamous cell carcinoma
childhood cancer
young adults
single molecule
circulating tumor