Endogenous stimulus-controlled estradiol@AIEgen-based covalent organic framework for reduction of myocardial ischemia/reperfusion injury.
Fang YuanCuiling ZhangXianzhu LuoXiaokun ShenYuezhong XianPublished in: Chemical communications (Cambridge, England) (2023)
ATP stimulus-responsive tetrahedral DNA-gated fluorescent covalent organic frameworks (COFs) were developed for estradiol (E2) delivery and controllable release. The fluorescent COFs with an efficient E2 loading showed great potential against myocardial ischemia and reperfusion injury.
Keyphrases
- ischemia reperfusion injury
- quantum dots
- living cells
- left ventricular
- estrogen receptor
- acute myocardial infarction
- single molecule
- label free
- circulating tumor
- oxidative stress
- cell free
- cerebral ischemia
- cancer therapy
- fluorescent probe
- heart failure
- human health
- coronary artery disease
- subarachnoid hemorrhage
- risk assessment
- brain injury