Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson's Disease.

Shanshan HuMeigui HuJian LiuBei ZhangZhen ZhangFiona H ZhouLiping Wang Jianghui Dong

Published in: Neuropsychiatric disease and treatment (2020)

These findings revealed that p-α-Synuclein and p-Tau proteins are key pathological events leading to neurodegeneration and motor dysfunctions in the mouse MPTP model of PD. Our data suggest that the interference with the GSK3β activity may be an effective approach for the treatment of PD.

Keyphrases

mouse model
cerebrospinal fluid
high glucose
signaling pathway
electronic health record
single cell
pi k akt
drug induced
machine learning
big data
protein kinase
combination therapy
data analysis
stress induced