In vivo Imaging of Cannabinoid Type 2 Receptors: Functional and Structural Alterations in Mouse Model of Cerebral Ischemia by PET and MRI.
Ruiqing NiAdrienne Müller HerdeAhmed HaiderClaudia KellerGeorgios LouloudisMarkus VaasRoger SchibliSimon M AmetameyJan KlohsLinjing MuPublished in: Molecular imaging and biology (2021)
This study revealed an increased [18F]RoSMA-18-d6 measure of CB2R and a reduced [18F]FDG measure of CMRglc in the ischemic striatum of tMCAO mice at subacute stage. [18F]RoSMA-18-d6 might be a promising PET tracer for detecting CB2R alterations in animal models of neuroinflammation without neuronal loss.
Keyphrases
- cerebral ischemia
- positron emission tomography
- pet imaging
- subarachnoid hemorrhage
- pet ct
- blood brain barrier
- brain injury
- computed tomography
- mouse model
- magnetic resonance imaging
- high resolution
- contrast enhanced
- single cell
- type diabetes
- traumatic brain injury
- inflammatory response
- adipose tissue
- diffusion weighted imaging
- cognitive impairment