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Synthesis of d-glyco-alkynone derivatives via carbonylative Sonogashira reaction.

Mariana P DarbemC Henrique A EstevesIsadora M de OliveiraJoel S ReisDaniel C PimentaHélio A Stefani
Published in: RSC advances (2019)
A carbonylative Sonogashira coupling approach to the synthesis of glyco-alkynones is described. Eighteen examples were obtained in moderate do nearly quantitative yields under mild conditions employing Mo(CO) 6 as a safe carbon monoxide source. Functionalization of the alkynyl moiety via cycloaddition with organic azides provided six examples of glyco-triazoles.
Keyphrases
  • high resolution
  • room temperature
  • electron transfer