Synthesis of d-glyco-alkynone derivatives via carbonylative Sonogashira reaction.
Mariana P DarbemC Henrique A EstevesIsadora M de OliveiraJoel S ReisDaniel C PimentaHélio A StefaniPublished in: RSC advances (2019)
A carbonylative Sonogashira coupling approach to the synthesis of glyco-alkynones is described. Eighteen examples were obtained in moderate do nearly quantitative yields under mild conditions employing Mo(CO) 6 as a safe carbon monoxide source. Functionalization of the alkynyl moiety via cycloaddition with organic azides provided six examples of glyco-triazoles.