Stability and compatibility of admixtures containing bupivacaine hydrochloride and ketorolac tromethamine for parenteral use.
Hani AbdeltawabJagdish Kumar JaiswalSimon W YoungDarren SvirskisAndrew HillManisha SharmaPublished in: European journal of hospital pharmacy : science and practice (2021)
BH/KT parenteral admixtures are chemically stable for a period of 4 weeks when stored at room temperature. The stability-indicating HPLC method is valid for BH/KT simultaneous determination in human plasma, facilitating pharmacokinetics studies.
Keyphrases
- simultaneous determination
- room temperature
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- tandem mass spectrometry
- ionic liquid
- ultra high performance liquid chromatography
- solid phase extraction
- liquid chromatography
- ms ms
- pain management
- mass spectrometry
- case control
- postoperative pain
- gestational age
- chronic pain