AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival.

Vedika MehraGiulia AgliardiJuliana DiasManar S ShafatAmaia Cadinanos GaraiLouisa GreenAlastair HotblackFred Arce VargasKarl S PeggsAnniek B van der WaartHarry DolstraMartin A PuleClaire Roddie

Published in: Journal for immunotherapy of cancer (2023)

Ultimately, AUTO1 generated with VIII may begin to overcome the product specific factors contributing to CD19+relapse.

Keyphrases

free survival
signaling pathway
cell proliferation